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In sites with such a wide target audience, it is important to address varying degrees of computer literacy as a form of localization.
There are varying degrees of computer literacy within each cultural user group. The implications of this need to be identified during a robust discovery process and central to the generation of the sites' interaction design.
I recommend a robust discovery and design process that emphasizes user-centered interaction design best practices.
Research-informed user-tested high-fidelity wireframe prototypes - that's the point in development to identify usability issues and adjust. Fail on paper, as it were, not post-launch!
'Getting it right' before engineering may require a greater time investment up-front, but it pays off.